Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E-deficient mice
TC Dawson, WA Kuziel, TA Osahar, N Maeda - Atherosclerosis, 1999 - Elsevier
The accumulation of circulating monocytes in the arterial wall is an early event in
atherosclerotic plaque formation. Monocyte chemoattractant protein-1 (MCP-1) has been
implicated as the primary source of monocyte chemoattractant functioning in these early
stages of atherogenesis. To determine whether the receptor for MCP-1, CC chemokine
receptor CCR2, plays a role in atherogenesis, CCR2-deficient animals were crossed with
mice lacking apo E, a well characterized model of atherosclerosis. While lipid levels were …
atherosclerotic plaque formation. Monocyte chemoattractant protein-1 (MCP-1) has been
implicated as the primary source of monocyte chemoattractant functioning in these early
stages of atherogenesis. To determine whether the receptor for MCP-1, CC chemokine
receptor CCR2, plays a role in atherogenesis, CCR2-deficient animals were crossed with
mice lacking apo E, a well characterized model of atherosclerosis. While lipid levels were …