[HTML][HTML] Methylation of Gata3 protein at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells

H Hosokawa, M Kato, H Tohyama, Y Tamaki… - Journal of Biological …, 2015 - ASBMB
Gata3 acts as a master regulator for T helper 2 (Th2) cell differentiation by inducing
chromatin remodeling of the Th2 cytokine loci, accelerating Th2 cell proliferation, and
repressing Th1 cell differentiation. Gata3 also directly transactivates the interleukin-5 (Il5)
gene via additional mechanisms that have not been fully elucidated. We herein identified a
mechanism whereby the methylation of Gata3 at Arg-261 regulates the transcriptional
activation of the Il5 gene in Th2 cells. Although the methylation-mimicking Gata3 mutant …