Fibroblast-specific β-catenin signaling dictates the outcome of AKI
D Zhou, H Fu, L Xiao, H Mo, H Zhuo… - Journal of the …, 2018 - journals.lww.com
AKI is a devastating condition with high morbidity and mortality. The pathologic features of
AKI are characterized by tubular injury, inflammation, and vascular impairment. Whether
fibroblasts in the renal interstitium have a role in the pathogenesis of AKI is unknown. In this
study, we investigated the role of fibroblast-specific β-catenin signaling in dictating the
outcome of AKI, using conditional knockout mice in which β-catenin was specifically ablated
in fibroblasts (Gli1-β-cat−/−). After ischemia-reperfusion injury (IRI), Gli1-β-cat−/− mice had …
AKI are characterized by tubular injury, inflammation, and vascular impairment. Whether
fibroblasts in the renal interstitium have a role in the pathogenesis of AKI is unknown. In this
study, we investigated the role of fibroblast-specific β-catenin signaling in dictating the
outcome of AKI, using conditional knockout mice in which β-catenin was specifically ablated
in fibroblasts (Gli1-β-cat−/−). After ischemia-reperfusion injury (IRI), Gli1-β-cat−/− mice had …