[PDF][PDF] T cell dysfunction in cancer

DS Thommen, TN Schumacher - Cancer cell, 2018 - cell.com
Cancer cell, 2018cell.com
Therapeutic reinvigoration of tumor-specific T cells has greatly improved clinical outcome in
cancer. Nevertheless, many patients still do not achieve durable benefit. Recent evidence
from studies in murine and human cancer suggest that intratumoral T cells display a broad
spectrum of (dys-) functional states, shaped by the multifaceted suppressive signals that
occur within the tumor microenvironment. Here we discuss the current understanding of T
cell dysfunction in cancer, the value of novel technologies to dissect such dysfunction at the …
Therapeutic reinvigoration of tumor-specific T cells has greatly improved clinical outcome in cancer. Nevertheless, many patients still do not achieve durable benefit. Recent evidence from studies in murine and human cancer suggest that intratumoral T cells display a broad spectrum of (dys-)functional states, shaped by the multifaceted suppressive signals that occur within the tumor microenvironment. Here we discuss the current understanding of T cell dysfunction in cancer, the value of novel technologies to dissect such dysfunction at the single cell level, and how our emerging understanding of T cell dysfunction may be utilized to develop personalized strategies to restore antitumor immunity.
cell.com