[PDF][PDF] The quest for a universal flu vaccine: headless HA 2.0
F Krammer - Cell host & microbe, 2015 - cell.com
Cell host & microbe, 2015•cell.com
Two recent publications report the design of immunogens based on the conserved stalk
domain of the influenza virus hemagglutinin. These new" headless" hemagglutinin
constructs recapitulate the epitopes recognized by broadly neutralizing antibodies and
induce broadly protective/heterosubtypic immunity in animal models, bringing us a step
closer to" universal" influenza virus vaccines.
domain of the influenza virus hemagglutinin. These new" headless" hemagglutinin
constructs recapitulate the epitopes recognized by broadly neutralizing antibodies and
induce broadly protective/heterosubtypic immunity in animal models, bringing us a step
closer to" universal" influenza virus vaccines.
Two recent publications report the design of immunogens based on the conserved stalk domain of the influenza virus hemagglutinin. These new "headless" hemagglutinin constructs recapitulate the epitopes recognized by broadly neutralizing antibodies and induce broadly protective/heterosubtypic immunity in animal models, bringing us a step closer to "universal" influenza virus vaccines.
cell.com