Highlights•Osteocytes regulate bone formation through a number of interacting signalling
pathways.•Osteocytes regulate bone resorption through controlling osteoclast activity and
directly through perilacunar remodelling.•Osteocytes represent attractive therapeutic targets
for bone diseases.Bone remodelling is an essential process for shaping and maintaining
bone mass in the mature skeleton. During our lifetime bone is constantly being removed by
osteoclasts and new bone is formed by osteoblasts. The activities of osteoclasts and …