[HTML][HTML] PINCH-1 is an obligate partner of integrin-linked kinase (ILK) functioning in cell shape modulation, motility, and survival
T Fukuda, K Chen, X Shi, C Wu - Journal of Biological Chemistry, 2003 - ASBMB
PINCH-1 is a widely expressed focal adhesion protein that forms a ternary complex with
integrin-linked kinase (ILK) and CH-ILKBP/actopaxin/α-parvin (abbreviated as α-parvin
herein). We have used RNA interference, a powerful approach of reverse genetics, to
investigate the functions of PINCH-1 and ILK in human cells. We report here the following.
First, PINCH-1 and ILK, but not α-parvin, are essential for prompt cell spreading and motility.
Second, PINCH-1 and ILK, like α-parvin, are crucial for cell survival. Third, PINCH-1 and ILK …
integrin-linked kinase (ILK) and CH-ILKBP/actopaxin/α-parvin (abbreviated as α-parvin
herein). We have used RNA interference, a powerful approach of reverse genetics, to
investigate the functions of PINCH-1 and ILK in human cells. We report here the following.
First, PINCH-1 and ILK, but not α-parvin, are essential for prompt cell spreading and motility.
Second, PINCH-1 and ILK, like α-parvin, are crucial for cell survival. Third, PINCH-1 and ILK …