To clear or to fear: An innate perspective on factor VIII immunity
JD Lai, MT Georgescu, C Hough, D Lillicrap - Cellular Immunology, 2016 - Elsevier
The enigma that is factor VIII immunogenicity remains ever pertinent in the treatment of
hemophilia A. Development of neutralizing antibodies against the therapeutic protein in 25–
30% of patients likely depends on the appropriate activation of the innate immune response
shortly following antigen encounter. Our understanding of this important immunological
synapse remains ill-defined. In this review, we examine the three distinct factors contributing
to the fate of factor VIII almost immediately after infusion: the characteristics of the protein …
hemophilia A. Development of neutralizing antibodies against the therapeutic protein in 25–
30% of patients likely depends on the appropriate activation of the innate immune response
shortly following antigen encounter. Our understanding of this important immunological
synapse remains ill-defined. In this review, we examine the three distinct factors contributing
to the fate of factor VIII almost immediately after infusion: the characteristics of the protein …