[HTML][HTML] Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies

TC Nichols, C Hough, H Agersø, M Ezban… - Journal of Thrombosis …, 2016 - Elsevier
Animal models of inherited bleeding disorders are important for understanding disease
pathophysiology and are required for preclinical assessment of safety prior to testing of
novel therapeutics in human and veterinary medicine. Experiments in these animals
represent important translational research aimed at developing safer and better treatments,
such as plasma‐derived and recombinant protein replacement therapies, gene therapies
and immune tolerance protocols for antidrug inhibitory antibodies. Ideally, testing is done in …