Mitochondria-targeted peptide accelerates ATP recovery and reduces ischemic kidney injury
HH Szeto, S Liu, Y Soong, D Wu… - Journal of the …, 2011 - journals.lww.com
The burst of reactive oxygen species (ROS) during reperfusion of ischemic tissues can
trigger the opening of the mitochondrial permeability transition (MPT) pore, resulting in
mitochondrial depolarization, decreased ATP synthesis, and increased ROS production.
Rapid recovery of ATP upon reperfusion is essential for survival of tubular cells, and
inhibition of oxidative damage can limit inflammation. SS-31 is a mitochondria-targeted
tetrapeptide that can scavenge mitochondrial ROS and inhibit MPT, suggesting that it may …
trigger the opening of the mitochondrial permeability transition (MPT) pore, resulting in
mitochondrial depolarization, decreased ATP synthesis, and increased ROS production.
Rapid recovery of ATP upon reperfusion is essential for survival of tubular cells, and
inhibition of oxidative damage can limit inflammation. SS-31 is a mitochondria-targeted
tetrapeptide that can scavenge mitochondrial ROS and inhibit MPT, suggesting that it may …