Relation of serum lipids and lipoproteins with progression of CKD: the CRIC study
M Rahman, W Yang, S Akkina, A Alper… - Clinical journal of the …, 2014 - journals.lww.com
Results Mean age of the study population was 58.2 years, and the mean GFR was 44.9
ml/min per 1.73 m 2; 48% of patients had diabetes. None of the lipid or lipoprotein measures
was independently associated with risk of the composite end point or rate of change in GFR.
However, there were significant (P= 0.01) interactions by level of proteinuria. In participants
with proteinuria< 0.2 g/d, 1-SD higher LDL-C was associated with a 26% lower risk of the
renal end point (hazard ratio [HR], 0.74; 95% confidence interval [95% CI], 0.59 to 0.92; P …
ml/min per 1.73 m 2; 48% of patients had diabetes. None of the lipid or lipoprotein measures
was independently associated with risk of the composite end point or rate of change in GFR.
However, there were significant (P= 0.01) interactions by level of proteinuria. In participants
with proteinuria< 0.2 g/d, 1-SD higher LDL-C was associated with a 26% lower risk of the
renal end point (hazard ratio [HR], 0.74; 95% confidence interval [95% CI], 0.59 to 0.92; P …