Diabetic nephropathy (DN) is a major life-threatening complication of diabetes. Renal
lesions affect glomeruli and tubules, but the pathogenesis is not completely understood.
Phospholipids and glycolipids are molecules that carry out multiple cell functions in health
and disease, and their role in DN pathogenesis is unknown. We employed high spatial
resolution MALDI imaging MS to determine lipid changes in kidneys of eNOS−/− db/db mice,
a robust model of DN. Phospholipid and glycolipid structures, localization patterns, and …