A combined epidemiologic and metabolomic approach improves CKD prediction
EP Rhee, CB Clish, A Ghorbani… - Journal of the …, 2013 - journals.lww.com
Metabolomic approaches have begun to catalog the metabolic disturbances that accompany
CKD, but whether metabolite alterations can predict future CKD is unknown. We performed
liquid chromatography/mass spectrometry–based metabolite profiling on plasma from 1434
participants in the Framingham Heart Study (FHS) who did not have CKD at baseline.
During the following 8 years, 123 individuals developed CKD, defined by an estimated GFR
of< 60 ml/min per 1.73 m 2. Numerous metabolites were associated with incident CKD …
CKD, but whether metabolite alterations can predict future CKD is unknown. We performed
liquid chromatography/mass spectrometry–based metabolite profiling on plasma from 1434
participants in the Framingham Heart Study (FHS) who did not have CKD at baseline.
During the following 8 years, 123 individuals developed CKD, defined by an estimated GFR
of< 60 ml/min per 1.73 m 2. Numerous metabolites were associated with incident CKD …