Transcriptomic evidence of immune activation in macroscopically normal-appearing and scarred lung tissues in idiopathic pulmonary fibrosis

IG Luzina, MV Salcedo, ML Rojas-Peña, AE Wyman… - Cellular …, 2018 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease manifested by overtly scarred
peripheral and basilar regions and more normal-appearing central lung areas. Lung tissues
from macroscopically normal-appearing (IPFn) and scarred (IPFs) areas of explanted IPF
lungs were analyzed by RNASeq and compared with healthy control (HC) lung tissues.
There were profound transcriptomic changes in IPFn compared with HC tissues, which
included elevated expression of numerous immune-, inflammation-, and extracellular matrix …