[HTML][HTML] Lysosomes integrate metabolic-inflammatory cross-talk in primary macrophage inflammasome activation
K Weber, JD Schilling - Journal of Biological Chemistry, 2014 - ASBMB
Macrophage dysfunction and inflammasome activation have been implicated in the
pathogenesis of diabetes and its complications. Prolonged inflammation and impaired
healing are hallmarks of the diabetic response to tissue injury, and excessive inflammasome
activation has been associated in these phenotypes. However, the mechanisms that
regulate the inflammasome in response to lipid metabolic and inflammatory stress are
incompletely understood. We have shown previously that IL-1β secretion is induced in …
pathogenesis of diabetes and its complications. Prolonged inflammation and impaired
healing are hallmarks of the diabetic response to tissue injury, and excessive inflammasome
activation has been associated in these phenotypes. However, the mechanisms that
regulate the inflammasome in response to lipid metabolic and inflammatory stress are
incompletely understood. We have shown previously that IL-1β secretion is induced in …