[HTML][HTML] Mechanisms of lung fibrosis resolution

SW Glasser, JS Hagood, S Wong, CA Taype… - The American journal of …, 2016 - Elsevier
SW Glasser, JS Hagood, S Wong, CA Taype, SK Madala, WD Hardie
The American journal of pathology, 2016Elsevier
Fibrogenesis involves a dynamic interplay between factors that promote the biosynthesis
and deposition of extracellular matrix along with pathways that degrade the extracellular
matrix and eliminate the primary effector cells. Opposing the often held perception that
fibrotic tissue is permanent, animal studies and clinical data now demonstrate the highly
plastic nature of organ fibrosis that can, under certain circumstances, regress. This review
describes the current understanding of the mechanisms whereby the lung is known to …
Fibrogenesis involves a dynamic interplay between factors that promote the biosynthesis and deposition of extracellular matrix along with pathways that degrade the extracellular matrix and eliminate the primary effector cells. Opposing the often held perception that fibrotic tissue is permanent, animal studies and clinical data now demonstrate the highly plastic nature of organ fibrosis that can, under certain circumstances, regress. This review describes the current understanding of the mechanisms whereby the lung is known to resolve fibrosis focusing on degradation of the extracellular matrix, removal of myofibroblasts, and the role of inflammatory cells. Although there are significant gaps in understanding lung fibrosis resolution, accelerated improvements in biotechnology and bioinformatics are expected to improve the understanding of these mechanisms and have high potential to lead to novel and effective restorative therapies in the treatment not only of pulmonary fibrosis, but also of a wide-ranging spectrum of chronic disorders.
Elsevier