[HTML][HTML] Subcytotoxic H2O2 stress triggers a release of transforming growth factor-β1, which induces biomarkers of cellular senescence of human diploid fibroblasts
C Frippiat, QM Chen, S Zdanov, JP Magalhaes… - Journal of Biological …, 2001 - ASBMB
Stress-induced premature senescence (SIPS) is induced 3 days after exposure of human
diploid fibroblasts to subcytotoxic oxidative stress with H 2 O 2, with appearance of several
biomarkers of replicative senescence. In this work, we show that transforming growth factor-
β1 (TGF-β1) regulates the induction of several of these biomarkers in SIPS: cellular
morphology, senescence-associated β-galactosidase activity, increase in the steady-state
level of fibronectin, apolipoprotein J, osteonectin, and SM22 mRNA. Indeed, the …
diploid fibroblasts to subcytotoxic oxidative stress with H 2 O 2, with appearance of several
biomarkers of replicative senescence. In this work, we show that transforming growth factor-
β1 (TGF-β1) regulates the induction of several of these biomarkers in SIPS: cellular
morphology, senescence-associated β-galactosidase activity, increase in the steady-state
level of fibronectin, apolipoprotein J, osteonectin, and SM22 mRNA. Indeed, the …