EGFR signaling promotes TGFβ-dependent renal fibrosis
J Chen, JK Chen, K Nagai, D Plieth, M Tan… - Journal of the …, 2012 - journals.lww.com
The mechanisms by which angiotensin II (Ang II) promotes renal fibrosis remain
incompletely understood. Ang II both stimulates TGFβ signaling and activates the EGF
receptor (EGFR), but the relative contribution of these pathways to renal fibrogenesis is
unknown. Using a murine model with EGFR-deficient proximal tubules, we demonstrate that
upstream activation of EGFR-dependent ERK signaling is critical for mediating sustained
TGFβ expression in renal fibrosis. Persistent activation of the Ang II receptor stimulated ROS …
incompletely understood. Ang II both stimulates TGFβ signaling and activates the EGF
receptor (EGFR), but the relative contribution of these pathways to renal fibrogenesis is
unknown. Using a murine model with EGFR-deficient proximal tubules, we demonstrate that
upstream activation of EGFR-dependent ERK signaling is critical for mediating sustained
TGFβ expression in renal fibrosis. Persistent activation of the Ang II receptor stimulated ROS …