Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes

T Gohda, MA Niewczas, LH Ficociello… - Journal of the …, 2012 - journals.lww.com
Elevated plasma concentrations of TNF receptors 1 and 2 (TNFR1 and TNFR2) predict
development of ESRD in patients with type 2 diabetes without proteinuria, suggesting these
markers may contribute to the pathogenesis of renal decline. We investigated whether
circulating markers of the TNF pathway determine GFR loss among patients with type 1
diabetes. We followed two cohorts comprising 628 patients with type 1 diabetes, normal
renal function, and no proteinuria. Over 12 years, 69 patients developed estimated GFR less …