Genetic or pharmacologic blockade of EGFR inhibits renal fibrosis
N Liu, JK Guo, M Pang, E Tolbert… - Journal of the …, 2012 - journals.lww.com
Although enhanced activation of the EGF receptor (EGFR) associates with the development
and progression of renal fibrosis, the mechanisms linking these observations are not
completely understood. Here, after unilateral ureteral obstruction (UUO), wild-type mice
exhibited sustained EGFR phosphorylation in the kidney and developed renal fibrosis that
was more severe than the renal fibrosis observed in waved-2 mice, which have reduced
EGFR tyrosine kinase activity. Waved-2 mice also showed fewer renal tubular cells arrested …
and progression of renal fibrosis, the mechanisms linking these observations are not
completely understood. Here, after unilateral ureteral obstruction (UUO), wild-type mice
exhibited sustained EGFR phosphorylation in the kidney and developed renal fibrosis that
was more severe than the renal fibrosis observed in waved-2 mice, which have reduced
EGFR tyrosine kinase activity. Waved-2 mice also showed fewer renal tubular cells arrested …