Corneal avascularity is necessary for the preservation of optimal vision. The cornea
maintains a dynamic balance between pro-and antiangiogenic factors that allows it to
remain avascular under normal homeostatic conditions; however, corneal avascularity can
be compromised by pathologic conditions that negate the cornea's” angiogenic privilege.”
The clinical relevance of corneal neovascularization has long been recognized, but
management of this condition has been hindered by a lack of safe and effective therapeutic …