Efficacy of haptoglobin administration in the early postoperative course of patients with a diagnosis of HELLP syndrome
H Yamamoto, S. Nishikawa, K. Yamazaki … - Journal of Obstetrics …, 2000 - Taylor & Francis
H Yamamoto, S. Nishikawa, K. Yamazaki, R. Kudo
Journal of Obstetrics and Gynaecology, 2000•Taylor & Francis1 Haemolysis is a major component of HELLP syndrome. Haemolysis causes serum
haptoglobin, a glycoprotein which binds free oxyhaemoglobin, to be consumed, resulting in
a rise of serum free haemoglobin. Free haemoglobin remains in the circulation in the early
postoperative course, possibly resulting in kidney damage. In this randomised study, the
efficacy of haptoglobin administration during the early postoperative course on preventing
signs of kidney damage in patients with HELLP syndrome was investigated.
haptoglobin, a glycoprotein which binds free oxyhaemoglobin, to be consumed, resulting in
a rise of serum free haemoglobin. Free haemoglobin remains in the circulation in the early
postoperative course, possibly resulting in kidney damage. In this randomised study, the
efficacy of haptoglobin administration during the early postoperative course on preventing
signs of kidney damage in patients with HELLP syndrome was investigated.
1 Haemolysis is a major component of HELLP syndrome. Haemolysis causes serum haptoglobin, a glycoprotein which binds free oxyhaemoglobin, to be consumed, resulting in a rise of serum free haemoglobin. Free haemoglobin remains in the circulation in the early postoperative course, possibly resulting in kidney damage. In this randomised study, the efficacy of haptoglobin administration during the early postoperative course on preventing signs of kidney damage in patients with HELLP syndrome was investigated.
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