The incidence of decreased red blood cell deformability in sepsis and the association with oxygen free radical damage and multiple-system organ failure
GW Machiedo, RJ Powell, BF Rush… - Archives of …, 1989 - jamanetwork.com
• We studied the incidence of decreased red blood cell deformability (RBCD) in sepsis and
the association between decreased RBCD and oxygen free radical generation (as
measured by malonyldialdehyde) and the occurrence of multiple-system organ failure
(MSOF). Patients were divided into three groups: septic (n= 28), nonseptic (n= 15), and
control (n= 5). Serial measurements of deformability index, malonyldialdehyde, and MSOF
were made. The deformability index for the septic group (0.23±0.17) was significantly less …
the association between decreased RBCD and oxygen free radical generation (as
measured by malonyldialdehyde) and the occurrence of multiple-system organ failure
(MSOF). Patients were divided into three groups: septic (n= 28), nonseptic (n= 15), and
control (n= 5). Serial measurements of deformability index, malonyldialdehyde, and MSOF
were made. The deformability index for the septic group (0.23±0.17) was significantly less …