Alternative Wnt pathways and receptors
R Van Amerongen - Cold Spring Harbor perspectives in …, 2012 - cshperspectives.cshlp.org
Cold Spring Harbor perspectives in biology, 2012•cshperspectives.cshlp.org
In addition to activating β-catenin/TCF transcriptional complexes, Wnt proteins can elicit a
variety of other responses. These are often lumped together under the denominator
“alternative” or “non-canonical” Wnt signaling, but they likely comprise distinct signaling
events. In this article, I discuss how the use of different ligand and receptor combinations is
thought to give rise to these alternative Wnt-signaling responses. Although many of the
biochemical details remain to be resolved, it is evident that alternative Wnt signaling plays …
variety of other responses. These are often lumped together under the denominator
“alternative” or “non-canonical” Wnt signaling, but they likely comprise distinct signaling
events. In this article, I discuss how the use of different ligand and receptor combinations is
thought to give rise to these alternative Wnt-signaling responses. Although many of the
biochemical details remain to be resolved, it is evident that alternative Wnt signaling plays …
In addition to activating β-catenin/TCF transcriptional complexes, Wnt proteins can elicit a variety of other responses. These are often lumped together under the denominator “alternative” or “non-canonical” Wnt signaling, but they likely comprise distinct signaling events. In this article, I discuss how the use of different ligand and receptor combinations is thought to give rise to these alternative Wnt-signaling responses. Although many of the biochemical details remain to be resolved, it is evident that alternative Wnt signaling plays important roles in regulating tissue morphogenesis during embryonic development.
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