Atorvastatin reduces proinflammatory markers in hypercholesterolemic patients
E Ascer, MC Bertolami, ML Venturinelli, V Buccheri… - Atherosclerosis, 2004 - Elsevier
BACKGROUND:: Reduction in cardiovascular events with statins has been in part attributed
to their anti-inflammatory properties. OBJECTIVE:: Evaluate the effects of atorvastatin on
levels of inflammatory markers, such as tumor necrosis factor-α (TNF), interleukins (IL-1 and
IL-6), soluble intercellular adhesion molecule-1 (sICAM-1) and C-reactive protein (CRP) in
hypercholesterolemic patients (LDL-cholesterol> 160mg/dL). METHODS AND RESULTS::
Two lipid-lowering regimens were taken for 8 weeks. One set of patients (n= 45, 26 men …
to their anti-inflammatory properties. OBJECTIVE:: Evaluate the effects of atorvastatin on
levels of inflammatory markers, such as tumor necrosis factor-α (TNF), interleukins (IL-1 and
IL-6), soluble intercellular adhesion molecule-1 (sICAM-1) and C-reactive protein (CRP) in
hypercholesterolemic patients (LDL-cholesterol> 160mg/dL). METHODS AND RESULTS::
Two lipid-lowering regimens were taken for 8 weeks. One set of patients (n= 45, 26 men …