Simvastatin induces interleukin-18 production in human peripheral blood mononuclear cells
HK Takahashi, S Mori, H Iwagaki, T Yoshino… - Clinical …, 2005 - Elsevier
The effects of statins on immune response depend on the inhibition of 3-hydroxy-3-
methylglutaryl coenzyme-A (HMG-CoA) reductase and leukocyte function-associated
antigen (LFA)-1, which is a ligand of intercellular adhesion molecule (ICAM)-1. Simvastatin,
an HMG-CoA reductase inhibitor with mild inhibition of LFA-1, induced the production of
interleukin (IL)-18, tumor necrosis factor (TNF)-α and interferon (IFN)-γ in human peripheral
blood mononuclear cells (PBMC). The IL-18 production is located upstream of the cytokine …
methylglutaryl coenzyme-A (HMG-CoA) reductase and leukocyte function-associated
antigen (LFA)-1, which is a ligand of intercellular adhesion molecule (ICAM)-1. Simvastatin,
an HMG-CoA reductase inhibitor with mild inhibition of LFA-1, induced the production of
interleukin (IL)-18, tumor necrosis factor (TNF)-α and interferon (IFN)-γ in human peripheral
blood mononuclear cells (PBMC). The IL-18 production is located upstream of the cytokine …
