Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation/CRP evaluation (PRINCE): a randomized trial and cohort study

MA Albert, E Danielson, N Rifai, PM Ridker… - Jama, 2001 - jamanetwork.com
ContextPlasma levels of the inflammatory biomarker C-reactive protein (CRP) predict
cardiovascular risk, and retrospective studies suggest that 3-hydroxy-3-methylglutaryl
coenzyme A reductase inhibitors (statins) may lower CRP in a manner largely independent
of low-density lipoprotein cholesterol (LDL-C). However, prospective trial data directly
evaluating this anti-inflammatory effect of statins are not available. ObjectiveTo test the
hypothesis that pravastatin has anti-inflammatory effects as evidenced by CRP reduction …