The NF-κB signaling pathway in human genetic diseases
G Courtois - Cellular and Molecular Life Sciences CMLS, 2005 - Springer
G Courtois
Cellular and Molecular Life Sciences CMLS, 2005•SpringerThe nuclear factor-κB (NF-κB) signaling pathway plays a key role in inflammation, immune
response, cell growth control and protection against apoptosis. Recently, it has been
associated with several distinct genetic diseases that exhibit a large spectrum of dysfunction,
such as skin inflammation, perturbed skin appendage development and
immunodeficiencies. In this review, a summary of the pathophysiological consequences of
impaired NF-κB activation in humans is provided with respect to the functions of the …
response, cell growth control and protection against apoptosis. Recently, it has been
associated with several distinct genetic diseases that exhibit a large spectrum of dysfunction,
such as skin inflammation, perturbed skin appendage development and
immunodeficiencies. In this review, a summary of the pathophysiological consequences of
impaired NF-κB activation in humans is provided with respect to the functions of the …
Abstract
The nuclear factor-κB (NF-κB) signaling pathway plays a key role in inflammation, immune response, cell growth control and protection against apoptosis. Recently, it has been associated with several distinct genetic diseases that exhibit a large spectrum of dysfunction, such as skin inflammation, perturbed skin appendage development and immunodeficiencies. In this review, a summary of the pathophysiological consequences of impaired NF-κB activation in humans is provided with respect to the functions of the molecules which are mutated.
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