Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions
Nature medicine, 2019•nature.com
Combining HLA-DQ–gluten tetramers with mass cytometry and RNA sequencing analysis,
we find that gluten-specific CD4+ T cells in the blood and intestines of patients with celiac
disease display a surprisingly rare phenotype. Cells with this phenotype are also elevated in
patients with systemic sclerosis and systemic lupus erythematosus, suggesting a way to
characterize CD4+ T cells specific for disease-driving antigens in multiple autoimmune
conditions.
we find that gluten-specific CD4+ T cells in the blood and intestines of patients with celiac
disease display a surprisingly rare phenotype. Cells with this phenotype are also elevated in
patients with systemic sclerosis and systemic lupus erythematosus, suggesting a way to
characterize CD4+ T cells specific for disease-driving antigens in multiple autoimmune
conditions.
Abstract
Combining HLA-DQ–gluten tetramers with mass cytometry and RNA sequencing analysis, we find that gluten-specific CD4+ T cells in the blood and intestines of patients with celiac disease display a surprisingly rare phenotype. Cells with this phenotype are also elevated in patients with systemic sclerosis and systemic lupus erythematosus, suggesting a way to characterize CD4+ T cells specific for disease-driving antigens in multiple autoimmune conditions.
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