Signaling of gp34 (OX40 ligand) induces vascular endothelial cells to produce a CC chemokine RANTES/CCL5
A Kotani, T Hori, Y Matsumura, T Uchiyama - Immunology letters, 2002 - Elsevier
We previously showed that gp34 (OX40 ligand) expressed on vascular endothelial cells is
not only involved in adhesion between activated T cells and endothelial cells but also by
itself able to transmit intracellular signals leading to expression of c-fos and c-jun mRNA
upon OX40 binding. In the present study, we searched for genes that were induced or
upregulated by gp34 signaling in human umbilical vein endothelial cells (HUVECs) to define
its downstream biological events. HUVECs expressing high levels of gp34 were stimulated …
not only involved in adhesion between activated T cells and endothelial cells but also by
itself able to transmit intracellular signals leading to expression of c-fos and c-jun mRNA
upon OX40 binding. In the present study, we searched for genes that were induced or
upregulated by gp34 signaling in human umbilical vein endothelial cells (HUVECs) to define
its downstream biological events. HUVECs expressing high levels of gp34 were stimulated …
