Myeloperoxidase (MPO) is the most toxic enzyme found in the azurophilic granules of
neutrophils. MPO utilizes H 2 O 2 to generate hypochlorous acid (HClO) and other reactive
moieties, which kill pathogens during infections. In contrast, in the setting of sterile
inflammation, MPO and MPO-derived oxidants are thought to be pathogenic, promoting
inflammation and causing tissue damage. In contrast, evidence also exists that MPO can
limit the extent of immune responses. Elevated MPO levels and activity are observed in a …