Sputum cell IL-1 receptor expression level is a marker of airway neutrophilia and airflow obstruction in asthmatic patients
Background Various clinical, biologic, or physiologic markers of asthma have been used to
identify patient clusters and potential targets for therapy. However, these identifiers
frequently overlap among the different asthma groups. For instance, both eosinophil and
neutrophil counts are often increased in the airways of asthmatic patients despite their
typical association with type 2 and type 17 immune response, respectively. Objectives We
sought to determine whether inflammatory gene expression is related to patterns of airway …
identify patient clusters and potential targets for therapy. However, these identifiers
frequently overlap among the different asthma groups. For instance, both eosinophil and
neutrophil counts are often increased in the airways of asthmatic patients despite their
typical association with type 2 and type 17 immune response, respectively. Objectives We
sought to determine whether inflammatory gene expression is related to patterns of airway …