Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure
M Tsujimoto, Y Goto, M Maruyama, A Hattori - Heart failure reviews, 2008 - Springer
M Tsujimoto, Y Goto, M Maruyama, A Hattori
Heart failure reviews, 2008•SpringerIt is becoming evident that several aminopeptidases belonging to the M1 family such as
aminopeptidase A (APA), placental leucine aminopeptidase (P-LAP), and adipocyte-derived
leucine aminopeptidase (A-LAP) play important roles in the regulation of blood pressure
under both the physiological and pathological conditions. They share HEXXH (X) 18 E zinc-
binding and GAMEN motifs essential for enzymatic activities. In this review, the current
situation regarding the biochemical characteristics of these enzymes including enzymatic …
aminopeptidase A (APA), placental leucine aminopeptidase (P-LAP), and adipocyte-derived
leucine aminopeptidase (A-LAP) play important roles in the regulation of blood pressure
under both the physiological and pathological conditions. They share HEXXH (X) 18 E zinc-
binding and GAMEN motifs essential for enzymatic activities. In this review, the current
situation regarding the biochemical characteristics of these enzymes including enzymatic …
Abstract
It is becoming evident that several aminopeptidases belonging to the M1 family such as aminopeptidase A (APA), placental leucine aminopeptidase (P-LAP), and adipocyte-derived leucine aminopeptidase (A-LAP) play important roles in the regulation of blood pressure under both the physiological and pathological conditions. They share HEXXH(X)18E zinc-binding and GAMEN motifs essential for enzymatic activities. In this review, the current situation regarding the biochemical characteristics of these enzymes including enzymatic properties and modes of action is summarized.
Springer