Cholangiocarcinoma (CCA) includes a heterogeneous group of biliary cancers with poor
prognosis. Several conditions, such as primary sclerosing cholangitis (PSC), are risk factors.
Noninvasive differential diagnosis between intrahepatic CCA and hepatocellular carcinoma
(HCC) is sometimes difficult. Accurate noninvasive biomarkers for PSC, CCA, and HCC are
not available. In the search for novel biomarkers, serum extracellular vesicles (EV) were
isolated from CCA (n= 43), PSC (n= 30), or HCC (n= 29) patients and healthy individuals …