[HTML][HTML] O-GlcNAc transferase promotes fatty liver-associated liver cancer through inducing palmitic acid and activating endoplasmic reticulum stress
Background & Aims O-GlcNAc transferase (OGT) is a unique glycosyltransferase involved in
metabolic reprogramming. We investigated the functional role of OGT in non-alcoholic fatty
liver disease-associated hepatocellular carcinoma (NAFLD-HCC). Methods The biological
function of OGT in NAFLD-HCC was determined by gain-or loss-of OGT functional assays in
vitro and in nude mice. OGT target factors and pathways were identified by liquid
chromatography-tandem mass spectrometry (LC-MS), promoter luciferase assay, DNA …
metabolic reprogramming. We investigated the functional role of OGT in non-alcoholic fatty
liver disease-associated hepatocellular carcinoma (NAFLD-HCC). Methods The biological
function of OGT in NAFLD-HCC was determined by gain-or loss-of OGT functional assays in
vitro and in nude mice. OGT target factors and pathways were identified by liquid
chromatography-tandem mass spectrometry (LC-MS), promoter luciferase assay, DNA …