[HTML][HTML] Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1
Pancreatic cancer, the fourth most prevalent cancer-related cause of death in the United
States, is a disease with a dismal survival rate of 5% 5 years after diagnosis. One of the
survival proteins responsible for its extraordinary ability to evade cell death is HSP70. A
naturally derived compound, triptolide, and its water-soluble prodrug, Minnelide, down-
regulate the expression of this protein in pancreatic cancer cells, thereby causing cell death.
However, the mechanism of action of triptolide has not been elucidated. Our study shows …
States, is a disease with a dismal survival rate of 5% 5 years after diagnosis. One of the
survival proteins responsible for its extraordinary ability to evade cell death is HSP70. A
naturally derived compound, triptolide, and its water-soluble prodrug, Minnelide, down-
regulate the expression of this protein in pancreatic cancer cells, thereby causing cell death.
However, the mechanism of action of triptolide has not been elucidated. Our study shows …