Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes.
GM Nassar, JD Morrow, LJ Roberts, FG Lakkis… - Journal of Biological …, 1994 - ASBMB
15-Lipoxygenase (15-LO) catalyzes hydroperoxidation of fatty acids, a reaction of potential
relevance to inflammation, membrane remodeling, and atherosclerosis. In human
leukocytes, 15-lipoxygenation of arachidonic acid produces 15-(S)-hydroxyeicosatetraenoic
acid and lipoxin A4, which suppress white cell chemotaxis, adherence, and activation, and
antagonize proinflammatory leukotrienes. Interleukin (IL)-13, produced by T-helper subset 2
(TH-2) lymphocytes, specifically and potently induced 15-LO gene expression and enzyme …
relevance to inflammation, membrane remodeling, and atherosclerosis. In human
leukocytes, 15-lipoxygenation of arachidonic acid produces 15-(S)-hydroxyeicosatetraenoic
acid and lipoxin A4, which suppress white cell chemotaxis, adherence, and activation, and
antagonize proinflammatory leukotrienes. Interleukin (IL)-13, produced by T-helper subset 2
(TH-2) lymphocytes, specifically and potently induced 15-LO gene expression and enzyme …