Lipoxygenase pathways in atherogenesis
L Zhao, CD Funk - Trends in cardiovascular medicine, 2004 - Elsevier
15-lipoxygenase-1 (also known as 12/15-LO in mice) and 5-LO/5-LO-activating protein
(FLAP) cascades play central roles in low-density lipoprotein oxidation and leukotriene
biosynthesis, respectively. Several genetic and expression studies unraveling an
association of the 5-LO/FLAP pathway to human cardiovascular disease have surfaced
recently. Experimental studies in 12/15-LO knockout, 15-LO-1 transgenic, and 5-LO
knockout mice on atherosclerotic backgrounds combined with gene expression data in …
(FLAP) cascades play central roles in low-density lipoprotein oxidation and leukotriene
biosynthesis, respectively. Several genetic and expression studies unraveling an
association of the 5-LO/FLAP pathway to human cardiovascular disease have surfaced
recently. Experimental studies in 12/15-LO knockout, 15-LO-1 transgenic, and 5-LO
knockout mice on atherosclerotic backgrounds combined with gene expression data in …