Ebola virus disease in mice with transplanted human hematopoietic stem cells
A Lüdtke, L Oestereich, P Ruibal, S Wurr… - Journal of …, 2015 - Am Soc Microbiol
A Lüdtke, L Oestereich, P Ruibal, S Wurr, E Pallasch, S Bockholt, WH Ip, T Rieger…
Journal of Virology, 2015•Am Soc MicrobiolThe development of treatments for Ebola virus disease (EVD) has been hampered by the
lack of small-animal models that mimick human disease. Here we show that mice with
transplanted human hematopoetic stem cells reproduce features typical of EVD. Infection
with Ebola virus was associated with viremia, cell damage, liver steatosis, signs of
hemorrhage, and high lethality. Our study provides a small-animal model with human
components for the development of EVD therapies.
lack of small-animal models that mimick human disease. Here we show that mice with
transplanted human hematopoetic stem cells reproduce features typical of EVD. Infection
with Ebola virus was associated with viremia, cell damage, liver steatosis, signs of
hemorrhage, and high lethality. Our study provides a small-animal model with human
components for the development of EVD therapies.
Abstract
The development of treatments for Ebola virus disease (EVD) has been hampered by the lack of small-animal models that mimick human disease. Here we show that mice with transplanted human hematopoetic stem cells reproduce features typical of EVD. Infection with Ebola virus was associated with viremia, cell damage, liver steatosis, signs of hemorrhage, and high lethality. Our study provides a small-animal model with human components for the development of EVD therapies.
American Society for Microbiology