[HTML][HTML] Identification of the MLL2 complex as a coactivator for estrogen receptor α
R Mo, SM Rao, YJ Zhu - Journal of Biological Chemistry, 2006 - ASBMB
A novel estrogen receptor (ER) α coactivator complex, the MLL2 complex, which consists of
MLL2, ASH2, RBQ3, and WDR5, was identified. ERα directly binds to the MLL2 complex
through two LXXLL motifs in a region of MLL2 near the C terminus in a ligand-dependent
manner. Disrupting the interaction between ERα and the MLL2 complex with small
interfering RNAs specific against MLL2 or an MLL2 fragment representing the interacting
region with ERα significantly inhibited the ERα transcription activity. The MLL2 complex was …
MLL2, ASH2, RBQ3, and WDR5, was identified. ERα directly binds to the MLL2 complex
through two LXXLL motifs in a region of MLL2 near the C terminus in a ligand-dependent
manner. Disrupting the interaction between ERα and the MLL2 complex with small
interfering RNAs specific against MLL2 or an MLL2 fragment representing the interacting
region with ERα significantly inhibited the ERα transcription activity. The MLL2 complex was …