A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development
J Cobb, A Dierich, Y Huss-Garcia… - Proceedings of the …, 2006 - pnas.org
Proceedings of the National Academy of Sciences, 2006•pnas.org
Deficiencies or mutations in the human pseudoautosomal SHOX gene are associated with a
series of short-stature conditions, including Turner syndrome, Leri–Weill dyschondrosteosis,
and Langer mesomelic dysplasia. Although this gene is absent from the mouse genome, the
closely related paralogous gene Shox2 displays a similar expression pattern in developing
limbs. Here, we report that the conditional inactivation of Shox2 in developing appendages
leads to a strong phenotype, similar to the human conditions, although it affects a different …
series of short-stature conditions, including Turner syndrome, Leri–Weill dyschondrosteosis,
and Langer mesomelic dysplasia. Although this gene is absent from the mouse genome, the
closely related paralogous gene Shox2 displays a similar expression pattern in developing
limbs. Here, we report that the conditional inactivation of Shox2 in developing appendages
leads to a strong phenotype, similar to the human conditions, although it affects a different …
Deficiencies or mutations in the human pseudoautosomal SHOX gene are associated with a series of short-stature conditions, including Turner syndrome, Leri–Weill dyschondrosteosis, and Langer mesomelic dysplasia. Although this gene is absent from the mouse genome, the closely related paralogous gene Shox2 displays a similar expression pattern in developing limbs. Here, we report that the conditional inactivation of Shox2 in developing appendages leads to a strong phenotype, similar to the human conditions, although it affects a different proximodistal limb segment. Furthermore, using this mouse model, we establish the cellular etiology of these defects and show that Shox2 acts upstream the Runx2 gene, a key regulator of chondrogenesis.
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