The IL‐23 axis in Salmonella gastroenteritis
I Godinez, AM Keestra, A Spees… - Cellular …, 2011 - Wiley Online Library
I Godinez, AM Keestra, A Spees, AJ Bäumler
Cellular microbiology, 2011•Wiley Online LibraryNon‐typhoidal Salmonella (NTS) serotypes cause a localized gastroenteritis in
immunocompetent individuals. In contrast, primary immunodeficiencies that impair
interleukin‐23 (IL‐23)‐dependent pathways are associated in humans with disseminated
NTS bloodstream infections (bacteraemia). The recent use of animal models has helped to
define the role the IL‐23 axis plays during NTS gastroenteritis, but additional work is needed
to elucidate how this host defence pathway prevents NTS bacteraemia.
immunocompetent individuals. In contrast, primary immunodeficiencies that impair
interleukin‐23 (IL‐23)‐dependent pathways are associated in humans with disseminated
NTS bloodstream infections (bacteraemia). The recent use of animal models has helped to
define the role the IL‐23 axis plays during NTS gastroenteritis, but additional work is needed
to elucidate how this host defence pathway prevents NTS bacteraemia.
Summary
Non‐typhoidal Salmonella (NTS) serotypes cause a localized gastroenteritis in immunocompetent individuals. In contrast, primary immunodeficiencies that impair interleukin‐23 (IL‐23)‐dependent pathways are associated in humans with disseminated NTS bloodstream infections (bacteraemia). The recent use of animal models has helped to define the role the IL‐23 axis plays during NTS gastroenteritis, but additional work is needed to elucidate how this host defence pathway prevents NTS bacteraemia.
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