Dendritic cells (DCs) form an extensive network in the intestinal lamina propria, which
orchestrates the mucosal immune response. Alterations in DC function can predispose to
inflammatory bowel disease, although by unknown mechanisms. We show that CD83, a
highly regulated DC cell surface protein, modulates the immune response to prevent colitis.
Mice with a conditional knockout of CD83 in DCs develop exacerbated colitis following
dextran sodium sulfate challenge, whereas mucosal overexpression of CD83 inhibits DC …