CD83 on murine APC does not function as a costimulatory receptor for T cells
B Kretschmer, K Lüthje, S Ehrlich, A Osterloh… - Immunology letters, 2008 - Elsevier
The transmembrane glycoprotein CD83 is rapidly upregulated on murine and human DC
upon maturation and therefore a costimulatory function for T cell activation has been
suggested. Studies employing human APC indeed showed that CD83 expression was
positively correlated to the stimulatory capacity of the APC. Murine APC that were CD83
deficient however, did not display a reduced capacity to activate T cells. To elucidate this
contradiction, we thoroughly compared the stimulatory capacity of CD83-overexpressing …
upon maturation and therefore a costimulatory function for T cell activation has been
suggested. Studies employing human APC indeed showed that CD83 expression was
positively correlated to the stimulatory capacity of the APC. Murine APC that were CD83
deficient however, did not display a reduced capacity to activate T cells. To elucidate this
contradiction, we thoroughly compared the stimulatory capacity of CD83-overexpressing …
