Retinoids exacerbate rat liver fibrosis by inducing the activation of latent TGF-β in liver stellate cells
M Okuno, H Moriwaki, S Imai, Y Muto, N Kawada… - Hepatology, 1997 - journals.lww.com
Liver stellate cells (SCs) play central roles in both the storage of retinol and the development
of liver fibrosis. The present study is aimed to understand the mechanism by which retinoic
acid (RA, an active metabolite of retinol) enhances hepatic fibrosis in rats. We tested the
effect of 9-cis-RA on several aspects in vitro rat SC cultures, including the activity of cellular
plasminogen activator (PA), messenger RNA (mRNA), and protein levels of transforming
growth factor-β (TGF-β) mRNA level of type-I procollagen, and the activity of type-I …
of liver fibrosis. The present study is aimed to understand the mechanism by which retinoic
acid (RA, an active metabolite of retinol) enhances hepatic fibrosis in rats. We tested the
effect of 9-cis-RA on several aspects in vitro rat SC cultures, including the activity of cellular
plasminogen activator (PA), messenger RNA (mRNA), and protein levels of transforming
growth factor-β (TGF-β) mRNA level of type-I procollagen, and the activity of type-I …