Stimulation of insulin secretion by gastric inhibitory polypeptide in man.
J Dupre, SA Ross, D Watson… - The Journal of Clinical …, 1973 - academic.oup.com
J Dupre, SA Ross, D Watson, JC Brown
The Journal of Clinical Endocrinology & Metabolism, 1973•academic.oup.comThe effect of very highly purified gastric inhibitory polypeptide (GIP) on insulin secretion in
man was tested in normal volunteers. Administration of physiological doses of GIP together
with glucose by IV infusion resulted in potentiation of the rise in IRI in the blood and
improvement in glucose tolerance. It is concluded that GIP is a potent insulinotropic
hormone and probably takes part in physiological potentiation of insulin secretion in
response to hyperglycemia during absorption of nutrients from the intestine.
man was tested in normal volunteers. Administration of physiological doses of GIP together
with glucose by IV infusion resulted in potentiation of the rise in IRI in the blood and
improvement in glucose tolerance. It is concluded that GIP is a potent insulinotropic
hormone and probably takes part in physiological potentiation of insulin secretion in
response to hyperglycemia during absorption of nutrients from the intestine.
Abstract
The effect of very highly purified gastric inhibitory polypeptide (GIP) on insulin secretion in man was tested in normal volunteers. Administration of physiological doses of GIP together with glucose by IV infusion resulted in potentiation of the rise in IRI in the blood and improvement in glucose tolerance. It is concluded that GIP is a potent insulinotropic hormone and probably takes part in physiological potentiation of insulin secretion in response to hyperglycemia during absorption of nutrients from the intestine.
Oxford University Press