Pharmacokinetic properties of 2′-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats
RS Geary, TA Watanabe, LA Truong, SUE Freier… - The Journal of …, 2001 - Elsevier
Plasma pharmacokinetics, biodistribution, excretion, and metabolism of four modified 20-
mer antisense oligonucleotides targeted to human intercellular adhesion molecule-1 mRNA
have been characterized in rats and compared with a first-generation phosphorothioate
oligodeoxynucleotide (PS ODN), ISIS 2302. The modified oligonucleotides contained 2′-O-
(2-methoxyethyl)(2′-O-MOE) ribose sugar modifications on all or a portion of the
nucleotides in the antisense sequence. The 2′-O-MOE-modified oligonucleotides were …
mer antisense oligonucleotides targeted to human intercellular adhesion molecule-1 mRNA
have been characterized in rats and compared with a first-generation phosphorothioate
oligodeoxynucleotide (PS ODN), ISIS 2302. The modified oligonucleotides contained 2′-O-
(2-methoxyethyl)(2′-O-MOE) ribose sugar modifications on all or a portion of the
nucleotides in the antisense sequence. The 2′-O-MOE-modified oligonucleotides were …
