Preanalytical factors affecting RIA measurement of plasma kisspeptin
R Ramachandran, M Patterson, KG Murphy… - Clinical …, 2008 - academic.oup.com
R Ramachandran, M Patterson, KG Murphy, WS Dhillo, S Patel, A Kazarian, MA Ghatei…
Clinical chemistry, 2008•academic.oup.comKisspeptins are peptide products of the KiSS-1 metastasis-suppressor (KISS1) gene and the
natural ligands of the G-protein–coupled receptor GPR54. KISS1 was initially investigated
as an antimetastasis gene. More recent studies have demonstrated that the kisspeptins are
potent stimulators of the hypothalamo-pituitarygonadal axis. Mice and humans with defective
kisspeptin signaling show hypogonadotrophic hypogonadism and impaired sexual
development (1, 2). Plasma kisspeptin concentrations are 2 pmol/L in men and nonpregnant …
natural ligands of the G-protein–coupled receptor GPR54. KISS1 was initially investigated
as an antimetastasis gene. More recent studies have demonstrated that the kisspeptins are
potent stimulators of the hypothalamo-pituitarygonadal axis. Mice and humans with defective
kisspeptin signaling show hypogonadotrophic hypogonadism and impaired sexual
development (1, 2). Plasma kisspeptin concentrations are 2 pmol/L in men and nonpregnant …
Kisspeptins are peptide products of the KiSS-1 metastasis-suppressor (KISS1) gene and the natural ligands of the G-protein–coupled receptor GPR54. KISS1 was initially investigated as an antimetastasis gene. More recent studies have demonstrated that the kisspeptins are potent stimulators of the hypothalamo-pituitarygonadal axis. Mice and humans with defective kisspeptin signaling show hypogonadotrophic hypogonadism and impaired sexual development (1, 2).
Plasma kisspeptin concentrations are 2 pmol/L in men and nonpregnant women. KiSS-1 mRNA is highly expressed in the placenta, and plasma kisspeptin concentrations increase dramatically, to thousands of picomoles per liter, during pregnancy (3). In addition, plasma kisspeptin is increased in women
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