Placental peptides regulating islet adaptation to pregnancy: clinical potential in gestational diabetes mellitus
S Simpson, L Smith, J Bowe - Current opinion in pharmacology, 2018 - Elsevier
Highlights•Failure of maternal β-cells to adequately adapt to the demands of pregnancy is
the main contributing factor in onset of GDM.•Of its many roles, the placenta is an essential
endocrine organ, maintaining pregnancy and regulating maternal adaptation.•Several
placental peptide hormones (eg placental lactogen, adipokines, HGF) regulate islet changes
in pregnancy in rodents.•The β-cell adaptations during pregnancy in humans is less
understood but is a major area of ongoing research.•Understanding role of placental signals …
the main contributing factor in onset of GDM.•Of its many roles, the placenta is an essential
endocrine organ, maintaining pregnancy and regulating maternal adaptation.•Several
placental peptide hormones (eg placental lactogen, adipokines, HGF) regulate islet changes
in pregnancy in rodents.•The β-cell adaptations during pregnancy in humans is less
understood but is a major area of ongoing research.•Understanding role of placental signals …