[HTML][HTML] LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection
PJ Vorster, J Guo, A Yoder, W Wang, Y Zheng… - Journal of Biological …, 2011 - ASBMB
Almost all viral pathogens utilize a cytoskeleton for their entry and intracellular transport. In
HIV-1 infection, binding of the virus to blood resting CD4 T cells initiates a temporal course
of cortical actin polymerization and depolymerization, a process mimicking the chemotactic
response initiated from chemokine receptors. The actin depolymerization has been
suggested to promote viral intracellular migration through cofilin-mediated actin treadmilling.
However, the role of the virus-mediated actin polymerization in HIV infection is unknown …
HIV-1 infection, binding of the virus to blood resting CD4 T cells initiates a temporal course
of cortical actin polymerization and depolymerization, a process mimicking the chemotactic
response initiated from chemokine receptors. The actin depolymerization has been
suggested to promote viral intracellular migration through cofilin-mediated actin treadmilling.
However, the role of the virus-mediated actin polymerization in HIV infection is unknown …
